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Hepatoprotective effect

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (2) Amyloid-β (1) Apoptosis (2) Endogenous Metabolite (1) HBV (1) Keap1-Nrf2 (1) NOD-like Receptor (NLR) (1)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (3) Metabolic Disease (14) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N5092

7-Methylcoumarin

Others Metabolic Disease

7-Methylcoumarin, a coumarin, exhibits strong hepatoprotective activity and potent antioxidant effect .
HY-N2155

Tubuloside A

Tubuloside A is a phenylethanoid glycoside with antioxidative effect and hepatoprotective activity.
HY-N0806

Sweroside

Others Metabolic Disease

Sweroside, isolated from Lonicera japonica, exhibits cytoprotective, anti-osteoporotic, and hepatoprotective effect .
HY-N11563

Potentillanoside A

Others Others

Potentillanoside A is a natural compound with hepatoprotective effect .

7-Methylcoumarin	Others	Metabolic Disease
7-Methylcoumarin, a coumarin, exhibits strong hepatoprotective activity and potent antioxidant effect .

Tubuloside A
Tubuloside A is a phenylethanoid glycoside with antioxidative effect and hepatoprotective activity.

Sweroside	Others	Metabolic Disease
Sweroside, isolated from Lonicera japonica, exhibits cytoprotective, anti-osteoporotic, and hepatoprotective effect .

Potentillanoside A	Others	Others
Potentillanoside A is a natural compound with hepatoprotective effect .

HY-W027126

Hepatoprotective agent-2	Apoptosis	Metabolic Disease
Hepatoprotective agent-2 (compound 2a), a 4-phenyl-tetrahydroquinoline derivative, displays a remarkable hepatoprotective effect. Hepatoprotective agent-2 has antiapoptotic activity. Hepatoprotective agent-2 notably prevents the chemically induced elevation of hepatic indicators associated with liver injury .

HY-Y0073

4-Hydroxyacetophenone P-hydroxyacetophenone	HBV	Infection Inflammation/Immunology
4-Hydroxyacetophenone (P-hydroxyacetophenone) is a key hepatoprotective and choleretic compound in Artemisia capillaris and A. morrisonensis, also has an anti-hepatitis B virus effect and anti-inflammatory effect .

HY-N7680

Neopuerarin A	Others	Metabolic Disease
Neopuerarin A is an isoflavones isolated from the water extraction of the dried roots of Pueraria lobata (Willd.). Neopuerarin A shows significant hepatoprotective effect .

HY-145888

Antioxidant agent-2	Amyloid-β	Neurological Disease
Antioxidant agent-2 (comp 3c), an BBB-penetrated antioxidant agent and a selective metal ions chelator, presents good neuroprotective effect and hepatoprotective effect for the study of Alzheimer’s disease .

HY-N10359

Isoandrographolide	NOD-like Receptor (NLR)	Inflammation/Immunology
Isoandrographolide possesses cell differentiation inducing and hepatoprotective effect. Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice .

HY-N7680A

Neopuerarin B	Others	Metabolic Disease
Neopuerarin B is an isoflavones isolated from the water extraction of the dried roots of Pueraria lobata (Willd.). Neopuerarin B shows significant hepatoprotective effect .

HY-N0975

1,11b-Dihydro-11b-hydroxymaackiain	Others	Metabolic Disease
1,11b-Dihydro-11b-hydroxymaackiain, a pterocarpane extract from the stems of Erycibe expansa, show a hepatoprotective effect .

HY-N12432

Glomeratide A	Others	Metabolic Disease
Glomeratide A is a benzophenone C-glucoside with hepatoprotective effects. Glomeratide A has a protective effect against d-galactosamine-induced hepatotoxicity in rat liver epithelial stem-like cells.

HY-N12426

Heilaohuguosu F	Others	Metabolic Disease
Heilaohuguosu F (compound 6) is a tetrahydrofuranolignan with weak hepatoprotective effects. Heilaohuguosu F has a mild protective effect against APAP-induced hepatotoxicity in HepG2 cells.

HY-106947

SY-640	Endogenous Metabolite	Metabolic Disease
SY-640 is an Acetamide derivative and has potent hepatoprotective effect. SY-640 reduces Propionibacterium acnes and Lipopolysaccharide-induced liver injury in mice .

HY-N4243

Neocurdione	Others	Metabolic Disease
Neocurdione is a hepatoprotective sesquiterpene isolated from Curcuma zedoaria rhizome. Neocurdione exerts potent effect on D-galactosamine- (D-Gain) and lipopolysaccharide- (LPS) induced acute liver injury in mice .

HY-N2998

Ganoderenic acid A	Others	Metabolic Disease
Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of β-glucuronidase. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury .

HY-N10380

Inonotusol F	Others	Metabolic Disease
Inonotusol F is a triterpene isolated from Inonotus obliquus. Inonotusol F shows hepatoprotective effects against D-galactosamine-induced WB-F344 cell damage .

HY-N4113

Glycycoumarin	Keap1-Nrf2 AMPK	Cancer
Glycycoumarin is a potent antispasmodic agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases .

HY-N0526

2"-O-Galloylhyperin	Others	Inflammation/Immunology
2"-O-Galloylhyperin, an active compound isolated from Pyrola incarnate Fisch., possesses anti-oxidative and anti-inflammatory activities. 2"-O-Galloylhyperin has hepatoprotective effect against oxidative stress-induced liver damage .

HY-N1969

3,3'-Di-O-methylellagic acid 3,8-Di-O-methylellagic acid
3,3'-Di-O-methylellagic acid obtained from Euphorbia adenochlora selectively inhibits the formation of acid-fastness in mycobacteria without retardation of their growth. 3,3'-di-O-methylellagic acid as a hepatoprotective compound is apparently due to its antioxidative effect .

HY-N7026

Celosin I	Others	Metabolic Disease
Celosin I, an oleanane-type triterpenoid saponin isolated from the seeds of Celosia argentea L, could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibits significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice .

HY-N1478

Gardenoside
Gardenoside is a natural compound found in Gardenia fruits, with hepatoprotective properties. Gardenoside suppresses the pain of chronic constriction injury by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis .

HY-N3240

Mulberrofuran C	Others	Neurological Disease
Mulberrofuran C (compound 11) is an isoprene based flavonoid compound that can be extracted from the root bark of mulberry trees. Mulberrofuran C has protective effect on t-BHP induced oxidative stress with EC₅₀ value of 1.02 μM. Mulberrofuran C has hepatoprotective and neuroprotective activities .

HY-N11457

Swertiaside

Others Others

Swertiaside is a natural product, that can be isolated from Swertia mussotii Franch .

Swertiaside	Others	Others
Swertiaside is a natural product, that can be isolated from Swertia mussotii Franch .

HY-N2447

Amarogentin 2 Publications Verification	AMPK Apoptosis	Metabolic Disease Cancer
Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK .

7-Methylcoumarin	Microorganisms Source classification Coumarins Metabolic Disease Phenylpropanoids Disease Research Fields	Others
7-Methylcoumarin, a coumarin, exhibits strong hepatoprotective activity and potent antioxidant effect .

Sweroside	Filago spathulata Presl. Structural Classification Monophenols Classification of Application Fields Labiatae Phenols Metabolic Disease Plants Disease Research Fields	Others
Sweroside, isolated from Lonicera japonica, exhibits cytoprotective, anti-osteoporotic, and hepatoprotective effect .

4-Hydroxyacetophenone P-hydroxyacetophenone	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Plants Compositae Disease Research Fields Inflammation/Immunology Artemisia capillaris Thunb.	HBV
4-Hydroxyacetophenone (P-hydroxyacetophenone) is a key hepatoprotective and choleretic compound in Artemisia capillaris and A. morrisonensis, also has an anti-hepatitis B virus effect and anti-inflammatory effect .

Potentillanoside A	Triterpenes Structural Classification Terpenoids Source classification Rosaceae Potentilla anserina Linn. Plants	Others
Potentillanoside A is a natural compound with hepatoprotective effect .

Neopuerarin A	Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Pueraria montana (Loureiro) Merrill Plants Disease Research Fields Isoflavones	Others
Neopuerarin A is an isoflavones isolated from the water extraction of the dried roots of Pueraria lobata (Willd.). Neopuerarin A shows significant hepatoprotective effect .

Isoandrographolide	Andrographis paniculata (Burm. F.) Nees Classification of Application Fields Acanthaceae Terpenoids Source classification Diterpenoids Plants Disease Research Fields Inflammation/Immunology	NOD-like Receptor (NLR)
Isoandrographolide possesses cell differentiation inducing and hepatoprotective effect. Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice .

Neopuerarin B	Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Pueraria montana (Loureiro) Merrill Plants Disease Research Fields Isoflavones	Others
Neopuerarin B is an isoflavones isolated from the water extraction of the dried roots of Pueraria lobata (Willd.). Neopuerarin B shows significant hepatoprotective effect .

1,11b-Dihydro-11b-hydroxymaackiain	Erycibe ferruginea C. Y. Wu Source classification Plants Other Flavonoids Convolvulaceae	Others
1,11b-Dihydro-11b-hydroxymaackiain, a pterocarpane extract from the stems of Erycibe expansa, show a hepatoprotective effect .

Glomeratide A	Structural Classification Polygala chinensis Linnaeus Source classification Polygalaceae Phenols Polyphenols Plants	Others
Glomeratide A is a benzophenone C-glucoside with hepatoprotective effects. Glomeratide A has a protective effect against d-galactosamine-induced hepatotoxicity in rat liver epithelial stem-like cells.

Heilaohuguosu F	Structural Classification Source classification Lignans Phenylpropanoids Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	Others
Heilaohuguosu F (compound 6) is a tetrahydrofuranolignan with weak hepatoprotective effects. Heilaohuguosu F has a mild protective effect against APAP-induced hepatotoxicity in HepG2 cells.

SY-640	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
SY-640 is an Acetamide derivative and has potent hepatoprotective effect. SY-640 reduces Propionibacterium acnes and Lipopolysaccharide-induced liver injury in mice .

Neocurdione	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Plants Curcuma phaeocaulis Valeton Disease Research Fields Zingiberaceae	Others
Neocurdione is a hepatoprotective sesquiterpene isolated from Curcuma zedoaria rhizome. Neocurdione exerts potent effect on D-galactosamine- (D-Gain) and lipopolysaccharide- (LPS) induced acute liver injury in mice .

Ganoderenic acid A	Triterpenes Human Gut Microbiota Metabolites other families Microorganisms Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields	Others
Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of β-glucuronidase. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury .

Inonotusol F	Natural Products Microorganisms Source classification	Others
Inonotusol F is a triterpene isolated from Inonotus obliquus. Inonotusol F shows hepatoprotective effects against D-galactosamine-induced WB-F344 cell damage .

Glycycoumarin	Classification of Application Fields Leguminosae Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer	Keap1-Nrf2 AMPK
Glycycoumarin is a potent antispasmodic agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases .

2"-O-Galloylhyperin	Flavonols Flavonoids Classification of Application Fields Pyrola calliantha H. Andr. Source classification Pyrolaceae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Pyrola incarnata Fisch. ex DC.	Others
2"-O-Galloylhyperin, an active compound isolated from Pyrola incarnate Fisch., possesses anti-oxidative and anti-inflammatory activities. 2"-O-Galloylhyperin has hepatoprotective effect against oxidative stress-induced liver damage .

Celosin I	Triterpenes Celosia argentea Linn. Classification of Application Fields Terpenoids Source classification Metabolic Disease Amaranthaceae Plants Disease Research Fields	Others
Celosin I, an oleanane-type triterpenoid saponin isolated from the seeds of Celosia argentea L, could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibits significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice .

Mulberrofuran C	Structural Classification Source classification Phenols Polyphenols Plants Moraceae Morus alba Linn.	Others
Mulberrofuran C (compound 11) is an isoprene based flavonoid compound that can be extracted from the root bark of mulberry trees. Mulberrofuran C has protective effect on t-BHP induced oxidative stress with EC₅₀ value of 1.02 μM. Mulberrofuran C has hepatoprotective and neuroprotective activities .

Swertiaside	Structural Classification Iridoids Swertia mussotii Terpenoids Source classification Gentianaceae Plants	Others
Swertiaside is a natural product, that can be isolated from Swertia mussotii Franch .

Amarogentin 2 Publications Verification	Structural Classification Gentiana scabra Bunge Iridoids Classification of Application Fields Terpenoids Source classification Gentianaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	AMPK Apoptosis
Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK .

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Hepatoprotective effect

Inhibitors & Agonists

NaturalProducts

Natural
Products